Preheat oven to 190 degrees C. Spray a glass baking dish with cooking spray.
Place tilapia fillets into prepared baking dish and bake in preheated oven for 10 minutes. Meanwhile stir together the mustard, Worcestershire sauce, lemon juice, garlic powder, oregano and Parmesan cheese.
When fish has cooked for 10 minutes spread with herb paste and sprinkle with bread crumbs. Continue baking for another 5 minutes until the topping is bubbly and golden.